The novelty of the idea is OK, but I must say, it does cheapen the look of the car somewhat.
The red (and later the blue) will irritate the eyes, especially with the hotspots.
I have seen it done dodgy in cars and yes it did cheapen the look of the car, but when done properly it looks great and actually improves the looks, the interior needs to be the right match though, some cars just don't have the interior to pull off a change in lighting.
I never found the blue to hurt my eyes, even on big trips. But it depends again on the way the lights have been installed. I would have to agree though, any instance where the light is bright in one spot and dimmer in another will definetely strain the eyes.
Nick